Research Projects & Collaborators

1. Introducing and evaluating Sepsis Advisor: a clinical decision support tool to help predict and prevent future unexpected deterioration of patients with COVID-19.
   
   Co-Principal Investigators: Andrew Seely, Shannon Fernando and Doug Barnaby
   Co-Investigators/Collaborators: Jeff Perry, Jamie Brehaut
   Funding: TOHAMO Innovation Fund $99,300 (2020-2022)
   Publication: SHOCK: April 2019 – Volume 51 – Issue 4 – p 416-422

2. Single center feasibility implementation of Donation Advisor – a novel decision support tool to assist with donation after circulatory determination of death.
   
   Co-Principal Investigators: Andrew Seely and Sonny Dhanani
   Co-Investigators/Collaborators: Jamie Brehaut, Timothy Ramsay, Sam Shemie, Maureen Meade, Jason Shahin, David Hartell, Andrew Healey, Jeffrey Zaltzman
   Funding: Physicians Services Incorporated (PSI) $195,000 (2020-2022)

3. Prophylaxis for patients at Risk to Eliminate Post-operative atrial fibrillation (PREP trial): a protocol for a randomized controlled feasibility study.
   
   Co-Principal Investigators: Andrew Seely, Sal Kanji and Heather Smith Co-investigators/Collaborators: Dean Ferguson, Diem Tran, Calum Redpath, Kednapa Thavorn, Donna Maziak, Patrick Villeneuve, Sudhir Sundaresan, Sebastien Gilbert Funding: TOHAMO Innovation Fund $91,100 (2020-2022)
   Publication: Trials volume 22, Article number: 384( 2021)

• Implementation of Donation Advisor, a personalized clinical decision support tool for improved efficiency and effectiveness of deceased organ donation and transplantation.
  
  Co-Principal Investigators: Andrew Seely and Sonny Dhanani
  Co-Investigators/Collaborators: Gordon Boyd, David Maslove, Jamie Brehaut, Tim Ramsay, Aimee Sarti, Kednapa Thavorn, Karen Burns, Jennifer Chandler, Michael Hartwick, Michaël Chassé, Marcelo Cypel, Markus Selzner, Frédérick d’Aragon, Maureen Meade, Andrew Healey, Damon Scales, Jason Shahin, Sam Shemie, Marat Slessarev, Matthew-John Weiss, Jeffrey Zaltzman, Darin Treleaven, Alp Sener, Jeff Warren
  Funding: Health Canada $609,365 (2019-2022) https://clinicaltrials.gov/ct2/show/NCT04661787

5. Introducing and evaluating Extubation Advisor™
   
   Co-Principal Investigators: Andrew Seely and Aimee Sarti
   Co-investigators/Collaborators: Dalibor Kubelik, Kednapa Thavorn, Tim Ramsay
   Funding: TOHAMO Innovation Fund $99,966 (2017-2019) https://clinicaltrials.gov/ct2/show/NCT02988167

6. Temperature, Heart and Respiratory Rate Investigation along with Variability Evaluation and Serum Biomarkers (THRRIVES).
   
   Principal Investigator: Andrew Seely
   Co-investigators/Collaborators: Dean Fergusson, Timothy Ramsay, Lothar Huebsch, Christopher Bredeson, Paul Macpherson, Bill Cameron, Lauralyn McIntyre, John Marshall, Arianne Buchan
   Funding: TOHAMO Innovation Fund $99,000 (Jan 2016-Dec 2016)
   Publication: Transplant Cell Ther. May 2021 5; S2666-6367 https://clinicaltrials.gov/ct2/show/NCT01848912

7. Socially Engineering Practice-Changing Surgical Quality Improvement Developed from the Grassroots in a Division to the Treetops of a Department.
   
   Principal Investigators: Andrew Seely
   Co-investigators/Collaborators: Jelena Ivanovic, Justin Presseau, Jeremy Grimshaw, Paul Hendry, Sudhir Sundaresan
   Funding: TOHAMO Innovation Fund $93,889 (Jan 2016-Dec 2016)

8. Continuous waveform analysis to improve prediction of time to death after withdrawal of life sustaining therapy in critically ill patients.
   
   Co-Principal Investigators: Andrew Seely and Sonny Dhanani
   Co-investigators/Collaborators: Tim Ramsay, Jason Shahin, Sam Shemie
   Funding: Physicians Services Incorporated (PSI) $168,000 (2016-2017)
   Publication: N Engl J Med. 2021 Jan 28;384(4): 345-352

9. CYCLE Pilot: A multi-centre pilot randomized clinical trial of early in-bed leg cycling versus routine physiotherapy in mechanically ventilated patients.
   
   Principal Investigator: Michelle Kho
   Co-Investigators: Alexander J Molloy, France Clarke, Margaret S Herridge, Karen K Y Koo, Jill Rudkowski, Andrew J E Seely, Joseph R Pellizzari, Jean-Eric Tarride, Marina Mourtzakis, Timothy Karachi, Deborah J Cook, the Canadian Critical Care Trials Group.
   Funding: CIHR operating grant $332,994 (2015-2017) Publication: BMJ Open 2016;6:e01165

10. CYCLE Pilot: A Pilot Randomized Study of Early Cycle Ergometry versus Routine Physiotherapy in Mechanically Ventilated Patients Role.
    
    Principal Investigator: Michelle Kho
    Co-Investigators: Alexander J Molloy, France Clarke, Margaret S Herridge, Karen K Y Koo, Jill Rudkowski, Andrew J E Seely, Joseph R Pellizzari, Jean-Eric Tarride, Marina Mourtzakis, Timothy Karachi, Deborah J Cook, the Canadian Critical Care Trials Group.
    Funding: Ontario Thoracic Society Funds Awarded: $31,350 (2015-2017) Publication: BMJ Open 2016;6:e01165

11. The NEUROlogically-impaired extubation Timing Trial (NEURO-ETT).
    
    Principal Investigator: Damon Scales
    Role: Co-Investigator
    Funding: CIHR Award $176,081 (2015-2018)

https://clinicaltrials.gov/ct2/show/NCT02920580

https://clinicaltrials.gov/ct2/show/NCT04291235

12. The Thoracic Peri-Operative Integrative Surgical Care Evaluation (POISE) Trial Lotte and John Hecht Memorial Foundation.
    
    Co-Principal Investigators: Andrew Seely and Dugald Seely
    Funding: Lotte and Hecht Foundation Award $ 3,853,888 over 8 years (2014-2022) Publication: The Journal of Alternative and Complementary Medicine Vol. 25, No. S1 Website: https://thechi.ca/research/#research-studies

13. Temperature, Heart and Respiratory Rate Investigation along with Variability Evaluation and Serum Biomarkers (THRRIVES).
    
    Role: Principal Investigator
    Co-investigators/Collaborators: Dean Fergusson, Tim Ramsay, Lothar Huebsch, Christopher Bredeson, Paul MacPherson, Bill Cameron, Arianne Buchan, Lauralyn McIntyre, John Marshall
    Funding: TOHAMO Innovation Fund $98,000 (Mar 2014-Dec 2015) https://clinicaltrials.gov/ct2/show/NCT01848912

14. Frequency of Screening and SBT Technique Trial: FASTWAVE RCT.
    
    Principal Investigator: Karen Burns
    Role: Leena Rizvi, Deborah J. Cook, Andrew J. E. Seely, Bram Rochwerg, Francois Lamontagne, John W. Devlin, Peter Dodek, Michael Mayette, Maged Tanios, Audrey Gouskos, Phyllis Kay, Susan Mitchell, Kenneth C. Kiedrowski, Nicholas S. Hill, and the Canadian Critical Care Trials Group
    Funding: CIHR $99,000 (2014-2016) Publication: Trials (2019) 20:587 https://clinicaltrials.gov/ct2/show/NCT02969226

15. Death Prediction and Physiology after Removal of Therapy (DePPaRT).
    
    Principal Investigator: Sonny Dhanani
    Co-Investigators: Sonny Dhanani, M.D., Laura Hornby, Amanda van Beinum, Nathan B. Scales, Melanie Hogue, Andrew Baker, Stephen Beed, J. Gordon Boyd, Jennifer A. Chandler, Michaël Chassé, Frederick D’Aragon, Cameron Dezfulian, Christopher J. Doig, Frantisek Duska,, Jan O. Friedrich, Dale Gardiner, Teneille Gofton, Dan Harvey, Christophe Herry, George Isac, Andreas H. Kramer, Demetrios J. Kutsogiannis, David Maslove, Maureen Meade, Sangeeta Mehta, Laveena Munshi, Loretta Norton, Giuseppe Pagliarello, Tim Ramsay, Katerina Rusinova, Damon Scales, Matous Schmidt, Andrew Seely, Jason Shahin, Marat Slessarev, Derek So, Heather Talbot, Walther N. K. A. van Mook, Petr Waldauf, Matthew Weiss, Jentina T. Wind, Sam D. Shemie,Canadian Critical Care Trials Group and Canadian Donation and Transplantation Research Program
    Funding: CIHR $722,574 (2013-2017) Publication: Intensive Care Med (2015) 41:1014–1028 Websites: https://cdtrp.ca/en/deppart-study/ http://www.ddepict.com/deppart-study.html https://www.ccctg.ca/News-Events/How-to-define-death.aspx

16. TryCYCLE (Critical Care Cycling to Improve Extremity Strength): A Single-Center, Prospective Pilot Study of the Safety and Feasibility of Early Rehabilitation using Cycle Ergometry in Mechanically Ventilated Patients.
    
    Principal Investigator: Michelle Kho
    Co-Investigators: Alexander J. Molloy, France J. Clarke, Daana Ajami, Magda McCaughan, Kristy Obrovac, Christina Murphy, Laura Camposilvan, Margaret, S. Herridge, Karen K. Y. Koo, Jill Rudkowski, Andrew J. E. Seely, Jennifer M. Zanni, Marina Mourtzakis, Thomas Piraino, Deborah J. Cook, Canadian Critical Care Trials Group
    Funding: CIHR $99,999 (2013-2014) Publication: PLoS One. 2016; 11(12): e0167561 https://clinicaltrials.gov/ct2/show/NCT01885442

17. Improving patient care through the implementation and evaluation of the Thoracic Surgery Quality monitoring, Information management and Clinic documentation.
    
    Principal Investigator: Andrew Seely
    Co-Investigators/Collaborators: Jelena Ivanovic, Donna E. Maziak, Farid M. Shamji, R. Sudhir Sundaresan, Sebastian Gilbert, Jennifer Smylie, Tim Ramsay
    Funding: TOHAMO $99,150 (2012-2013) Website: https://ottawatmm.org/